Bischler-Napieralski Reaction in Phosphorus Pentoxide-Pyridine. IV. Synthesis of 1-Acetonylisoquinoline Derivatives

Synthesis of 5-Methoxy-4-benzyloxazoles from Tyrosine and m-Tyrosine under Bischler-Napieralski Conditions*

Oxazoles are interesting from both a pharmacological and a chemical point of view. For example, they are known to interact with various proteins such as sodium-dependent excitatory amino acid transporters [1] or DNA repair protein OG-alkylguanine DNAalkyl-transferase [2], and furthermore, they display bacteriostatic [3] and antiinflammatory activity [4]. Additionally, oxazoles provide useful en...

Synthesis of Phosphorus Derivatives via Multicomponent Reactions

Stable derivatives of oxaphosphaphenanthrenes were prepared using multicomponent reactions of 3-bromo-2-naphthol, dialkyl acetylenedicarboxylate and trimethyl or triphenyl phosphite under microwave conditions with good yields. 

An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydroeudistomin Y

A novel synthetic methodology has been developed for the synthesis of dihydro-β-carboline derivatives employing oxidative amidation-Bischler-Napieralski reaction conditions using tryptamine and 2,2-dibromo-1-phenylethanone as key starting materials. A number of dihydro-β-carboline derivatives have been synthesized in moderate to good yields using this methodology. Attempts were made towards the...

Imido-pyridine Ti(IV) compounds: synthesis of unusual imido-amido heterobimetallic derivatives.

The reaction of lithiated picolines and [TiCl3(η(5)-C5Me5)] leads to several bridging or terminal imido compounds, each of which can be selectively formed by controlling the stoichiometry and temperature. Specifically, the dinuclear imido-bridged [TiCl(η(5)-C5Me5)(μ-NR)]2 (1a, NR = 2-imido-3-picoline; 1b, NR = 2-imido-5-picoline) species and the unusual Ti-Li imido-amido heterobimetallic comple...

Synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions via Phosphorus pentoxide supported on alumina (P2O5/Al2O3) catalyzed tandem reaction of Aldehyde with dimedone